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CFM 1571 hydrochloride is the stimulator of the nitric oxide receptor, soluble guanylatecyclase (sGC) with an EC50 and IC50 of 5.49 μM and 2.84 μM, respectively. Soluble guanylatecyclase (sGC) is a key signal-transduction enzyme activated by nitric oxide (NO). CFM 1571 hydrochloride has the potential for the research of cardiovascular and other diseases .
Prepro-ANF (56-92), human is a human atrial natriuretic factor precursor. Prepro-ANF (56-92), human is also a guanylatecyclase activator that enhances particulate guanylatecyclase activity in the renal membrane and renal unit .
Vericiguat-d3 (BAY1021189-d3) hydrochloride is a deuterated Vericiguat with tracer functionality. Vericiguat is an orally available stimulator of guanylatecyclase .
SGC agonist 2 is a potent agonist of soluble guanylatecyclase (SGC). Soluble guanylatecyclase is a key signal transduction enzyme in the NO-sGC-cGMP signaling pathway. SGC agonist 2 has the potential for the research of cardiovascular disease (heart failure, pulmonary hypertension, angina, myocardial infarction) and fibrotic diseases (renal fibrosis, systemic sclerosis) (extracted from patent WO2021219088A1, compound 031) .
Guanylin (mouse, rat), a petide, is composed of 15 amino acids. Guanylin (mouse, rat) is an activator of intestinal guanylatecyclase. Guanylin (mouse, rat) can be used for the research of diarrhea .
Ataciguat (HMR-1766) is a nitric oxide-independent soluble guanylatecyclase (sGC) activator. Ataciguat is able to activate the ferric heme-iron redox form of sGC that stimulate the production of cyclic GMP (cGMP). Ataciguat exhibits vasodilator effects .
SGC agonist 1 is a potent agonist of soluble guanylatecyclase (SGC). SGC agonist 1 improves solubility combined with high cell permeability. SGC agonist 1 has the potential for the research of cardiovascular disease (extracted from patent WO2016030354A1, compound 18A) .
Zagociguat is the stimulator of soluble guanylatecyclase. Zagociguat increases nitric oxide (NO) signaling leading to an increase in cyclic guanosine monophosphate production. Zagociguat has the potential for the research of noncentral nervous system (CNS) disorders .
Linaclotide is a potent and selective guanylatecyclase C agonist; developed for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic constipation.
MM 419447, a linaclotide metabolite, is a guanylatecyclase-C agonist. MM 419447 has the potential for the research of the irritable bowel syndrome with constipation (IBS-C) .
Runcaciguat is an orally active stimulator of soluble guanylatecyclase, and is used in the research of cardiovascular and renal diseases combined with selective partial adenosine A1 receptor agonists .
Olinciguat (IW-1701) is an oral guanylatecyclase (sGC) stimulator with concentration-dependent stimulation of sGC in purified rat and human enzyme assays and a whole cell assay .
Dolcanatide is an orally active GC-C(guanylatecyclase-C) agonist. Dolcanatide shows laxative, anti-nociceptive and anti-inflammatory activity. Dolcanatide can be used in inflammatory bowel disease research .
Riociguat- 13C,d6 is the 13C and deuterium labeled Riociguat (HY-14779). Riociguat is an oral stimulator of soluble guanylatecyclase (sGC) used in the treatment of pulmonary hypertension.
(Rac)-MGV354 is the racemate of MGV354. MGV354 is a soluble guanylatecyclase (sGC) activator with EC50s of <0.5 nM, and 5 nM in CHO and GTM-3 E cells, respectively .
Praliciguat (IW-1973) is a potent and orally active soluble guanylatecyclase stimulator, enhances NO signaling, acts as a vasodilator. Praliciguat (IW-1973) stimulates sGC in HEK-293 cells with an EC50 of 197 nM .
Guanylin(human), a 15-amino acid peptide, is an endogenous intestinal guanylatecyclase activator. Guanylin(human) is mainly found in gastrointestinal tract which regulates electrolytead water transport in intestinal and renal epithelia through cyclic GMP-dependent mechanism .
Guanylin(human) TFA, a 15-amino acid peptide, is an endogenous intestinal guanylatecyclase activator. Guanylin(human) TFA is mainly found in gastrointestinal tract which regulates electrolytead water transport in intestinal and renal epithelia through cyclic GMP-dependent mechanism .
BAY 41-2272 is an orally active and soluble guanylatecyclases (sGC) activator, which increases sGC activity by 400-fold in synergy with NO. BAY 41-2272 potently unloaded the heart, increased cardiac output, thus can be used for cardiovascular diseases research .
Plecanatide, an analogue of Uroguanylin, is an orally active guanylatecyclase-C (GC-C) receptor agonist. Plecanatide activates GC-C receptors to stimulate cGMP synthesis with an EC50 of 190 nM in T84 cells assay. Plecanatide shows anti-inflammatory activity in models of murine colitis .
Methylene blue (Basic Blue 9) is a guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS) inhibitor. Methylene blue is a vasopressor and is often used as a dye in several medical procedures. Methylene blue through the nitric oxide syntase/guanylatecyclase signalling pathway to reduce prepulse inhibition. Methylene blue is a REDOX cycling compound and able to cross the blood-brain barrier. Methylene blue is a Tau aggregation inhibitor. Methylene blue reduces cerebral edema, attenuated microglial activation and reduced neuroinflammation .
Methylene blue (Basic Blue 9) hydrate is a guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS) inhibitor. Methylene blue is a vasopressor and is often used as a dye in several medical procedures. Methylene blue hydrate through the nitric oxide syntase/guanylatecyclase signalling pathway to reduce prepulse inhibition. Methylene blue hydrate is a REDOX cycling compound and able to cross the blood-brain barrier. Methylene blue hydrate is a Tau aggregation inhibitor. Methylene blue hydrate reduces cerebral edema, attenuated microglial activation and reduced neuroinflammation .
Plecanatide acetate, an analogue of Uroguanylin, is an orally active guanylatecyclase-C (GC-C) receptor agonist. Plecanatide acetate activates GC-C receptors to stimulate cGMP synthesis with an EC50 of 190 nM in T84 cells assay. Plecanatide acetate can be used for the research of chronic idiopathic constipation, and it also shows anti-inflammatory activity in models of murine colitis .
Isatin (Indoline-2,3-dione) is a potent inhibitor of monoamine oxidase (MAO) with an IC50 of 3 μM. Also binds to central benzodiazepine receptors (IC50 against clonazepam, 123 μM) . Also acts as an antagonist of both atrial natriuretic peptide stimulated and nitric oxide-stimulated guanylatecyclase activity . Shows effect on the serotonergic system .
BAY-747 is an orally active and brain-penetrant stimulator of soluble guanylatecyclase (sGC). BAY-747 reverses L-NAME induced memory impairments and enhances cognition of rats in the object location task (OLT). BAY-747 also decreases blood pressure in both conscious normotensive and spontaneously hypertensive rats (SHR). BAY-747 improves function of the skeletal muscle associated with Duchenne muscular dystrophy (DMD) in mdx/mTRG2 mice model .
Methylene blue (Basic Blue 9) is a guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS) inhibitor. Methylene blue is a vasopressor and is often used as a dye in several medical procedures. Methylene blue through the nitric oxide syntase/guanylatecyclase signalling pathway to reduce prepulse inhibition. Methylene blue is a REDOX cycling compound and able to cross the blood-brain barrier. Methylene blue is a Tau aggregation inhibitor. Methylene blue reduces cerebral edema, attenuated microglial activation and reduced neuroinflammation .
Linaclotide is a potent and selective guanylatecyclase C agonist; developed for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic constipation.
MM 419447, a linaclotide metabolite, is a guanylatecyclase-C agonist. MM 419447 has the potential for the research of the irritable bowel syndrome with constipation (IBS-C) .
Dolcanatide is an orally active GC-C(guanylatecyclase-C) agonist. Dolcanatide shows laxative, anti-nociceptive and anti-inflammatory activity. Dolcanatide can be used in inflammatory bowel disease research .
Prepro-ANF (56-92), human is a human atrial natriuretic factor precursor. Prepro-ANF (56-92), human is also a guanylatecyclase activator that enhances particulate guanylatecyclase activity in the renal membrane and renal unit .
Guanylin (mouse, rat), a petide, is composed of 15 amino acids. Guanylin (mouse, rat) is an activator of intestinal guanylatecyclase. Guanylin (mouse, rat) can be used for the research of diarrhea .
Guanylin(human), a 15-amino acid peptide, is an endogenous intestinal guanylatecyclase activator. Guanylin(human) is mainly found in gastrointestinal tract which regulates electrolytead water transport in intestinal and renal epithelia through cyclic GMP-dependent mechanism .
Guanylin(human) TFA, a 15-amino acid peptide, is an endogenous intestinal guanylatecyclase activator. Guanylin(human) TFA is mainly found in gastrointestinal tract which regulates electrolytead water transport in intestinal and renal epithelia through cyclic GMP-dependent mechanism .
Plecanatide, an analogue of Uroguanylin, is an orally active guanylatecyclase-C (GC-C) receptor agonist. Plecanatide activates GC-C receptors to stimulate cGMP synthesis with an EC50 of 190 nM in T84 cells assay. Plecanatide shows anti-inflammatory activity in models of murine colitis .
Uroguanylin-15 (Rat) is a biological active peptide. (Uroguanylin is a natriuretic peptide, a hormone that regulates sodium excretion by the kidney when excess NaCl is consumed. Uroguanylin and guanylin are related peptides that activate common guanylatecyclase signaling molecules in the intestine and kidney. Uroguanylin was isolated from urine and duodenum but was not detected in extracts from the colon of rats.)
Plecanatide acetate, an analogue of Uroguanylin, is an orally active guanylatecyclase-C (GC-C) receptor agonist. Plecanatide acetate activates GC-C receptors to stimulate cGMP synthesis with an EC50 of 190 nM in T84 cells assay. Plecanatide acetate can be used for the research of chronic idiopathic constipation, and it also shows anti-inflammatory activity in models of murine colitis .
Isatin (Indoline-2,3-dione) is a potent inhibitor of monoamine oxidase (MAO) with an IC50 of 3 μM. Also binds to central benzodiazepine receptors (IC50 against clonazepam, 123 μM) . Also acts as an antagonist of both atrial natriuretic peptide stimulated and nitric oxide-stimulated guanylatecyclase activity . Shows effect on the serotonergic system .
NPR1 Protein, a receptor for atrial natriuretic peptide NPPA/ANP and brain natriuretic peptide NPPB/BNP, initiates signaling cascades with guanylate cyclase activity upon ligand binding. Essential vasoactive hormones, these peptides regulate cardiovascular homeostasis. NPR1 significantly contributes to vascular tone and fluid balance regulation in the cardiovascular system through its role as a receptor for these natriuretic peptides. NPR1 Protein, Human (P.pastoris, His) is the recombinant human-derived NPR1 protein, expressed by P. pastoris , with N-His labeled tag. The total length of NPR1 Protein, Human (P.pastoris, His) is 441 a.a., with molecular weight of ~51-75 kDa.
GCAP1 Proteinas, a pivotal regulator in the visual system, modulates retinal guanylyl cyclase activity based on intracellular calcium concentrations. Under low calcium, GCAP1 stimulates retinal guanylyl cyclase for dark state recovery in rod photoreceptors. Elevated calcium inhibits guanylyl cyclase activity, a crucial aspect of rod photoreceptor phototransduction. Additionally, GCAP1 may contribute to light response and recovery in cone photoreceptors under bright light. The protein's homodimeric structure enhances its regulatory capabilities in the visual signaling pathway. GCAP1 Protein, Human (sf9) is the recombinant human-derived GCAP1 protein, expressed by Sf9 insect cells , with tag free. and with residual Gly-Pro in N-terminal (not related to functional changes) mutation. The total length of GCAP1 Protein, Human (sf9) is 201 a.a., with molecular weight of ~20 kDa.
The GCAP1 protein is a key regulator in the visual system, regulating retinal guanylyl cyclase activity in response to intracellular calcium concentration. Under low calcium conditions, GCAP1 stimulates retinal guanylyl cyclase to return rod photoreceptors to the dark state. GCAP1 Protein, Human (sf9, His-GST) is the recombinant human-derived GCAP1 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of GCAP1 Protein, Human (sf9, His-GST) is 201 a.a., with molecular weight of ~42 kDa.
GUCY2C, a guanylyl cyclase, crucially catalyzes cGMP synthesis from GTP. As a receptor for E. coli heat-stable enterotoxin, GUCY2C significantly stimulates cGMP accumulation in mammalian cells, emphasizing its role in mediating responses to specific external stimuli and showcasing intricate regulatory mechanisms in cellular signaling. GUCY2C/Guanylyl cyclase C Protein, Rat (HEK293, Myc, His) is the recombinant rat-derived GUCY2C/Guanylyl cyclase C protein, expressed by HEK293 , with N-His, C-Myc labeled tag. The total length of GUCY2C/Guanylyl cyclase C Protein, Rat (HEK293, Myc, His) is 407 a.a., with molecular weight of ~51.4 kDa.
Riociguat- 13C,d6 is the 13C and deuterium labeled Riociguat (HY-14779). Riociguat is an oral stimulator of soluble guanylatecyclase (sGC) used in the treatment of pulmonary hypertension.
Vericiguat-d3 (BAY1021189-d3) hydrochloride is a deuterated Vericiguat with tracer functionality. Vericiguat is an orally available stimulator of guanylatecyclase .
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